ABSTRACT
Sepsis is a kind of systemic inflammatroy response syndrome (SIRS) induced by severe infection,operation,and trauma,with high mortality rate,treatment cost,and high consumption of medical resources.It has caused a great burden to the medical industry and even the national economy.Therefore,it is urgent to find effective treatment methods for sepsis.At present,the sepsis has been treated with certain drugs pointing at its pathogenesis,such as antibiotics,glucocorticoids,and vasoactive drugs.,but the therapeutic effect is not ideal,with many side effects,poor prognosis,and high clinical mortality.Based on the overall macro-dialectical thinking mode,and with the unique effect and low side effect,traditional Chinese medicine (TCM) has attracted the attention from researchers and clinicians around the world for treatment of sepsis.In recent years,some traditional Chinese medicine prescriptions,Chinese patent medicines,single Chinese medicines and active ingredients are increasingly used as new drugs to prevent and treat sepsis.Such treatment methods have been widely recognized and have reduced the mortality and inflammatory indexes of patients to a certain extent,playing an important role in the prevention and treatment of sepsis.In this paper,the actions of nuclear factor kappa B (NF-κB) signal pathway in sepsis as well as the advances in research of NF-κB signal pathway-related proteins in Chinese medicine for sepsis were reviewed.
ABSTRACT
Xiaoqinglong decoction,first recorded by Zhang Zhongjing in traditional Chinese medicine (TCM) classic text Shang Han Lun (Treatise on Cold Damage Diseases),has eight herbal components including Herb Ephedrae (Mahuang),Radix Paeoniae Alba (Shaoyao),Radix Asari (Xixin),Rhizoma Zingiberis (Ganjiang),Glycyrrhiza Uralensis (Gancao),Ramulus Cinnamomi (Cuizhi),Rhizoma Pinelliae (Banxia) and Fructus Schisandrae (Wuweizi).Fingerprints of HPLC for single herb and herb-pair including Mahuang-Gancao,Mahuang-Guizhi,Shaoyao-Guizhi,Shaoyao-Gancao,Wuweizi-Xixin were analyzed.Based on the HPLC of single herb and herbal pair,we discussed the character of the Xiaoqinglong decoction and explored the scientific connotation of the compatibility of medicines in prescription.
ABSTRACT
Ulcerative colitis (UC) is a chronic and relapsing condition of the intestinal inflammation of unknown etiology and remains one of the most intractable gastrointestinal diseases, impairing quality of life and carrying a high risk of colorectal cancer in patients with UC. Currently, aminosalicylic acid, steroid hormone, and immunosuppressor are the main drugs for treating UC. However, all of them can not cure UC once and for all. In recent years, many scholars attempted to find new drugs in the extracts and active compounds from herbs for the prevention and treatment of UC. The paper summarized the status of nuclear factor kappa B (NF-κB) signal pathway of UC, and those anti-inflammation Chinese materia medica regarded proteins and enzymes of NF-κB pathway as targets.
ABSTRACT
Clinical evidences demonstrated the effects of Chinese materia medica (CMM) on allergic diseases. However, the bioactive components in CMM and their mechanims of actions remain unkown. The progress of pharmacological studies on the anti-alleric effects of multi-herb formulation, herbal extracts/fraction, and pure compounds of CMM was summerized, which showed the characteristics of multi-component, multi-target, and multi-mechanism of CMM effects. This review provides the information for clinical use of anti-allergic CMM and drug discovery of anti-allergic CMM products.
ABSTRACT
Virus is a kind of pathogen which has greatly threat-ened human lives and is severely harmful to human’ s health. It is featured by rapid transmission and high mortality. At present there is no efficacious anti-virus western medicine. Some kinds of traditional Chinese medicines show certain restrictive effect a-gainst virus as natural materials and become a hot spot. This pa-per proceeds from experimental study on anti-virus activity and action mechanism of febrifuge and detoxifying herbs, and eluci-dates the important role of febrifuge and detoxifying herbs in anti-virus effect to provide evidence for screening anti-virus Chinese medicine in clinic.
ABSTRACT
Objective To observe the bacteriostatic effect of single herbs, traditional complex prescription and ultra-micro powder of Qiweibaizhusan. Methods The inhibiting zone and MIC of single herb and compound of Qiweibaizhusan on Escherichia coli, Staphylococcus aureus, Eubacterium aerofaciens, Pseudomonas aeruginosa, Salmonella sp, Saccharomyces cerevisiaes and Candida glabrata were measured by filter paper method. Results The growth of the tested bacteria and yeast except Staphylococcus aureus and Salmonella sp were inhibited by ginseng. The antibacterial effect of licorice was the best, and only Pseudomonas aeruginosa’s growth was not inhibited by licorice. The growth of Staphylococcus aureus and Eubacterium aerofaciens were inhibited by Agastache rugosa. The growth of Escherichia coli, Staphylococcus aureus, Eubacterium aerofaciens and Pseudomonas aeruginosa were inhibited by Poria cocos. Only Eubacterium aerofaciens’s growth was inhibited by Radix aucklandiae and fried Atractylodes macrocephala. The growth of all the bacteria and yeast were not inhibited by Radix puerariae. The growth of Staphylococcus aureus, Eubacterium aerofaciens and Salmonella sp were inhibited by the traditional decoction and ultra-micro powder of complex prescription of Qiweibaizhusan, and all the MIC of ultra-micro powder were smaller than the traditional decoction. Conclusion The main antibacterial component of Qiweibaizhusan was ginseng and licorice. The inhibiting effect of ultra-micro powder on bacteria was better than traditional decoction of Qiweibaizhusan in vitro.